The Therapeutic Potential of the Labdane Diterpenoid Forskolin
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Date
2019
Authors
Salehi, Bahare
Staniak, Mariola
Czopek, Katarzyna
Stępień, Anna
Dua, Kamal
Wadhwa, Ridhima
Chellappan, Dinesh Kumar
Sytar, Oksana
Brestic, Marian
Bhat, Namrata Ganesh
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological e ect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.
Description
Keywords
forskolin, plant secondary metabolites, Coleus forskohlii, cAMP pathway
Citation
Appl. Sci. 2019, 9(19), 4089