Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications

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dc.contributor.authorSharifi-Rad, Javad
dc.contributor.authorQuispe, Cristina
dc.contributor.authorAyatollahi, Seyed Abdulmajid
dc.contributor.authorKobarfard, Farzad
dc.contributor.authorStaniak, Mariola
dc.contributor.authorStępień, Anna
dc.contributor.authorCzopek, Katarzyna
dc.contributor.authorSen, Surjit
dc.contributor.authorAcharya, Krishnendu
dc.contributor.authorMatthews, Karl R.
dc.contributor.authorSener, Bilge
dc.contributor.authorDevkota, Hari Prasad
dc.contributor.authorKırkın, Celale
dc.contributor.authorOzçelik, Beraat
dc.contributor.authorVictoriano, Montserrat
dc.contributor.authorMartorell, Miquel
dc.contributor.authorSuleria, Hafiz Ansar Rasul
dc.contributor.authorAlshehri, Mohammed M.
dc.contributor.authorChandran, Deepak
dc.contributor.authorKumar, Manoj
dc.contributor.authorCruz-Martins, Natalia
dc.contributor.authorCho, William C.
dc.date.accessioned2026-02-04T10:45:23Z
dc.date.available2026-02-04T10:45:23Z
dc.date.issued2021
dc.description.abstractThe Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as asthma, diabetes, arthritis, impotence, amnesia, hypertension, anxiety, stress, cancer, neurodegenerative, and cardiovascular diseases, and many others. Among them, Withania somnifera (L.) Dunal is the most widely addressed species from a pharmacological and agroindustrial point of view. In this sense, this review provides an overview of the folk uses, phytochemical composition, and biological activity, such as antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activity of W. somnifera, although more recently other species have also been increasingly investigated. In addition, their health-promoting effects, i.e., antistress, anxiolytic, adaptogenic, antirheumatoid arthritis, chemoprotective, and cardiorespiratory-enhancing abilities, along with safety and adverse effects are also discussed.
dc.identifier.citationJournal of Food Quality, 2021, 8985179, 14 pages, 2021
dc.identifier.doi10.1155/2021/8985179
dc.identifier.issn0146-9428
dc.identifier.urihttps://bc.iung.pl/handle/123456789/4713
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1155/2021/8985179
dc.language.isoen
dc.publisherWiley
dc.titleChemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications
dc.typeArticle
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