Biological Activity of Monoterpene-Based Scaffolds: A Natural Toolbox for Drug Discovery

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dc.contributor.authorMołdoch, Jarosław
dc.contributor.authorAgacka-Mołdoch, Monika
dc.contributor.authorJóźwiak, Grzegorz
dc.contributor.authorWojtunik-Kulesza, Karolina
dc.date.accessioned2025-03-27T09:21:39Z
dc.date.available2025-03-27T09:21:39Z
dc.date.issued2025-03-27
dc.description.abstractOne of the most common strategies used in drug design is the molecular scaffold approach, which combines traditional medicine based on natural active compounds derived from plants with modern synthetic drug development. Designing new compounds based on natural skeletons enables extensive modifications of both bioavailability and biological activity. An excellent example of a natural molecular scaffold is the monoterpenes group, which serves as a core structure for building more complex molecules by attaching various chemical groups. Their ability to interact with biological targets, combined with structural versatility, makes them promising molecular scaffolds in pharmaceutical research and green chemistry applications. This review paper focuses on selected monoterpenes (carvacrol, carvone, citral, menthol, menthone, β-pinene, thymol, and verbenone), which are frequently used as molecular scaffolds. The newly designed derivatives exhibit various biological activities, including anticancer, antibacterial, antiviral, neuroprotective, and many others.
dc.description.sponsorshipThis research received no external funding
dc.identifier.citationMolecules 2025, 30, 1480
dc.identifier.doi10.3390/molecules30071480
dc.identifier.issn1420-3049
dc.identifier.urihttps://bc.iung.pl/handle/123456789/3260
dc.language.isoen_US
dc.publisherMDPI
dc.subjectmonoterpenes
dc.subjectmolecular scaffold
dc.subjectcarvacrol
dc.subjectcarvone
dc.subjectcitral
dc.subjectmenthol
dc.subjectβ-pinene
dc.subjectthymol
dc.subjectverbenone
dc.subjectmenthone
dc.titleBiological Activity of Monoterpene-Based Scaffolds: A Natural Toolbox for Drug Discovery
dc.typeArticle
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