Seseli foliosum (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation

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dc.contributor.authorNersezashvili, Mariam
dc.contributor.authorBerashvili, Dali
dc.contributor.authorJokhadze, Malkhaz
dc.contributor.authorMetreveli, Mariam
dc.contributor.authorŚwiątek, Łukasz
dc.contributor.authorSalwa, Kinga
dc.contributor.authorPecio, Łukasz
dc.contributor.authorWojtanowski, Krzysztof Kamil
dc.contributor.authorSkiba, Adrianna
dc.contributor.authorKorona-Głowniak, Izabela
dc.contributor.authorZengin, Gökhan
dc.contributor.authorSkalicka-Woźniak, Krystyna
dc.date.accessioned2025-02-13T15:41:10Z
dc.date.available2025-02-13T15:41:10Z
dc.date.issued2025-02-05
dc.description.abstractThe genus Seseli L. (Apiaceae family) is widespread across Europe and Asia, with ten species identified in Georgia. Among these, Seseli foliosum (Somm. et Levier) Manden., is notable for its unique pharmacological properties. To our knowledge, comprehensive phytochemical and biological investigations have not yet been conducted. The primary aim of this research is to explore the chemical and biological properties of S. foliosum, thereby enhancing its potential applications in medicine and related fields. Different chromatographic techniques were utilized to isolate individual compounds and to identify the chemical composition of S. foliosum MeOH and Et2O extracts from seeds and roots. A battery of biological assays (antimicrobial, antioxidant, enzymatic, anxiolytic, and cytotoxic) were employed to assess the pharmacological properties of the extracts. The results from gas chromatography with mass spectrometry (GC/MS) revealed that both MeOH and Et2O extracts contain a diverse array of compounds, including monoterpenoids, sesquiterpenoids, and phenolic compounds. Furanocoumarin edultin was isolated from the MeOH extract by liquid–liquid separation (LLS). The MeOH extracts exhibited important antioxidant, enzyme inhibitory, and antimicrobial activities with notable efficacy against Staphylococcus aureus (MIC 125 μg/mL) and Candida glabrata (MIC 62.5 μg/mL). Underground Et2O extracts showed advanced cytotoxic activity, particularly against hypopharyngeal carcinoma cells (CC50 22.33 μg/mL and 27.16 μg/mL, respectively). The study provides a wide-range analysis of the phytochemical composition and biological activities of S. foliosum, highlighting its potential as a source of bioactive compounds. These findings contribute to the understanding of the therapeutic potential of S. foliosum and lay the groundwork for further pharmacological and clinical research.
dc.description.sponsorshipThe research was funded by Medical University of Lublin DS28.
dc.identifier.citationMolecules 2025, 30, 725
dc.identifier.doi10.3390/molecules30030725
dc.identifier.issn1420-3049
dc.identifier.urihttps://bc.iung.pl/handle/123456789/2625
dc.publisherMDPI
dc.subjectcoumarin
dc.subjectvolatiles
dc.subjectbacteria
dc.subjectfungi
dc.subjectcytotoxicity
dc.subjectantioxidant
dc.subjectanti-enzymatic
dc.subjectchemistry
dc.subjectcentrifugal partition chromatography CPC
dc.titleSeseli foliosum (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation
dc.typeArticle
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