Phytochemical Profiling, Anti-Inflammatory Action, and Human Gut Microbiota-Assisted Digestion of Rheum officinale Petiole and Root Extracts—An In Vitro Study

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dc.contributor.authorLiudvytska, Oleksandra
dc.contributor.authorKowalczyk, Mariusz
dc.contributor.authorKrzyżanowska-Kowalczyk, Justyna
dc.contributor.authorMichaś, Karolina
dc.contributor.authorMichalak, Maria
dc.contributor.authorBalcerczyk, Aneta
dc.contributor.authorSkowrońska, Weronika
dc.contributor.authorRównicki, Marcin
dc.contributor.authorBazylko, Agnieszka
dc.contributor.authorOlszewska, Monika A.
dc.contributor.authorKolodziejczyk-Czepas, Joanna
dc.date.accessioned2025-11-03T06:54:56Z
dc.date.available2025-11-03T06:54:56Z
dc.date.issued2025-11-01
dc.description.abstractBackground/Objectives: Rheum officinale, an ethnomedicinal plant, has roots widely employed in modern pharmacological formulations. However, many of its biological activities remain only partly recognized. Furthermore, the metabolome and biological activity of its edible petioles, often considered a waste product, have received limited scientific attention. Methods and Results: The examination of anti-inflammatory properties of both root and petiole extracts (1–50 µg/mL) revealed the inhibition of the pro-inflammatory cytokine release from human peripheral blood mononuclear cells, a reduction in ALOX5 gene expression in human umbilical vein endothelial cells, and the significant inhibition (>60%) of cyclooxygenase-2 and 5-lipoxygenase activities. Importantly, no cytotoxic effects were detected at the tested concentrations. Conclusions: The petiole extract demonstrated anti-inflammatory efficiency comparable to, or exceeding that of the root extract, suggesting that R. officinale petioles could be valuable source of bioactive compounds for future investigations.
dc.description.sponsorshipNCN 2018/31/B/NZ9/01238
dc.identifier.citationNutrients 2025, 17, 3455 doi:10.3390/nu17213455
dc.identifier.doi10.3390/nu17213455
dc.identifier.issn2072-6643
dc.identifier.urihttps://bc.iung.pl/handle/123456789/3835
dc.language.isoen
dc.publisherMDPI
dc.subjectanti-inflammatory
dc.subjectcyclooxygenase-2
dc.subject5-lipoxygenase
dc.subjectendothelial cells
dc.subjectRheum officinale
dc.subjectRhei Radix et Rhizoma
dc.subjectmetabolite profiling
dc.subjectstilbenes
dc.subjectanthraquinones
dc.titlePhytochemical Profiling, Anti-Inflammatory Action, and Human Gut Microbiota-Assisted Digestion of Rheum officinale Petiole and Root Extracts—An In Vitro Study
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