Browsing by Author "Sharifi-Rad, Javad"

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    Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications
    (Wiley, 2021) Sharifi-Rad, Javad; Quispe, Cristina; Ayatollahi, Seyed Abdulmajid; Kobarfard, Farzad; Staniak, Mariola; Stępień, Anna; Czopek, Katarzyna; Sen, Surjit; Acharya, Krishnendu; Matthews, Karl R.; Sener, Bilge; Devkota, Hari Prasad; Kırkın, Celale; Ozçelik, Beraat; Victoriano, Montserrat; Martorell, Miquel; Suleria, Hafiz Ansar Rasul; Alshehri, Mohammed M.; Chandran, Deepak; Kumar, Manoj; Cruz-Martins, Natalia; Cho, William C.
    The Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as asthma, diabetes, arthritis, impotence, amnesia, hypertension, anxiety, stress, cancer, neurodegenerative, and cardiovascular diseases, and many others. Among them, Withania somnifera (L.) Dunal is the most widely addressed species from a pharmacological and agroindustrial point of view. In this sense, this review provides an overview of the folk uses, phytochemical composition, and biological activity, such as antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activity of W. somnifera, although more recently other species have also been increasingly investigated. In addition, their health-promoting effects, i.e., antistress, anxiolytic, adaptogenic, antirheumatoid arthritis, chemoprotective, and cardiorespiratory-enhancing abilities, along with safety and adverse effects are also discussed.
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    Euphorbia-Derived Natural Products with Potential for Use in Health Maintenance
    (MDPI, 2019) Salehi, Bahare; Iriti, Marcello; Vitalini, Sara; Antolak, Hubert; Pawlikowska, Ewelina; Kręgiel, Dorota; Sharifi-Rad, Javad; Oyeleye, Sunday I.; Ademiluyi, Adedayo O.; Czopek, Katarzyna; Staniak, Mariola; Custódio, Luísa; Coy-Barrera, Ericsson; Segura-Carretero, Antonio; de la Luz Cádiz-Gurrea, María; Capasso, Raffaele; Cho, William C.; Seca, Ana M. L.
    Euphorbia genus (Euphorbiaceae family), which is the third largest genus of angiosperm plants comprising ca. 2000 recognized species, is used all over the world in traditional medicine, especially in the traditional Chinese medicine. Members of this taxa are promptly recognizable by their specialized inflorescences and latex. In this review, an overview of Euphorbia-derived natural products such as essential oils, extracts, and pure compounds, active in a broad range of biological activities, and with potential usages in health maintenance, is described. The chemical composition of essential oils from Euphorbia species revealed the presence of more than 80 phytochemicals, mainly oxygenated sesquiterpenes and sesquiterpenes hydrocarbons, while Euphorbia extracts contain secondary metabolites such as sesquiterpenes, diterpenes, sterols, flavonoids, and other polyphenols. The extracts and secondary metabolites from Euphorbia plants may act as active principles of medicines for the treatment of many human ailments, mainly inflammation, cancer, and microbial infections. Besides, Euphorbia-derived products have great potential as a source of bioactive extracts and pure compounds, which can be used to promote longevity with more health.
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    Santalum Genus: phytochemical constituents, biological activities and health promoting-effects
    (De Gruyter, 2022) Sharifi-Rad, Javad; Quispe, Cristina; Turgumbayeva, Aknur; Mertdinç, Zehra; Tütüncü, Sena; Aydar, Elif Feyza; Özçelik, Beraat; Stępień-Warda, Anna; Staniak, Mariola; Koziróg, Anna; Otlewska, Anna; Antolak, Hubert; Sen, Surjit; Acharya, Krishnendu; Lapava, Natallia; Emamzadeh-Yazdi, Simin; Martorell, Miquel; Kumar, Manoj; Varoni, Elena Maria; Iriti, Marcello; Calina, Daniela
    Santalum genus belongs to the family of Santalaceae, widespread in India, Australia, Hawaii, Sri Lanka, and Indonesia, and valued as traditional medicine, rituals and modern bioactivities. Sandalwood is reported to possess a plethora of bioactive compounds such as essential oil and its components (α-santalol and β-santalol), phenolic compounds and fatty acids. These bioactives play important role in contributing towards biological activities and health-promoting effects in humans. Pre-clinical and clinical studies have shown the role of sandalwood extract as antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroleptic, antihyperglycemic, antihyperlipidemic, and anticancer activities. Safety studies on sandalwood essential oil (EO) and its extracts have proven them as a safe ingredient to be utilized in health promotion. Phytoconstituents, bioactivities and traditional uses established sandalwood as one of the innovative materials for application in the pharma, food, and biomedical industry.
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    The agricultural and therapeutic potential of Lavatera thuringiaca L. (Malvaceae)
    (Acta Agrobotanica, 2023) Staniak, Mariola; Kowalska, Iwona; Ruhul, Amin; Sharifi-Rad, Javad; Czopek, Katarzyna; Stępień-Warda, Anna
    One of the poorly recognized plant species well adapted to cultivation in temperate climate conditions is Lavatera thuringiaca L. It is a common species in Europe, but so far has not found much economic use. Few literature data report its high production potential, favorable chemical composition of biomass, resistance to adverse stress conditions, and medicinal properties. e biomass can be used for fodder and energy purposes and as forage for bees and other pollinators. L. thuringiaca can also be useful for the management of fallow soils or marginal land and for the reclamation of contaminated land. In turn, the presence of biologically active compounds offers opportunities for its use in medicine. Wider diversification of cultivated species is a key to ensuring food security and economic sustainability, especially in view of the observed climate change. In this context, an extensive review of literature dealing with taxonomic studies, morphological diversity and biological properties of L. thuringiaca, and the potential for multipurpose use of this species has been carried out.
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    The Therapeutic Potential of the Labdane Diterpenoid Forskolin
    (MDPI, 2019) Salehi, Bahare; Staniak, Mariola; Czopek, Katarzyna; Stępień, Anna; Dua, Kamal; Wadhwa, Ridhima; Chellappan, Dinesh Kumar; Sytar, Oksana; Brestic, Marian; Bhat, Namrata Ganesh; Kumar, Nanjangud Venkatesh Anil; del Mar Contreras, María; Sharopov, Farukh; Cho, William C.; Sharifi-Rad, Javad
    Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological e ect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.