Browsing by Author "Sharifi-Rad, Javad"

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    Euphorbia-Derived Natural Products with Potential for Use in Health Maintenance
    (MDPI, 2019) Salehi, Bahare; Iriti, Marcello; Vitalini, Sara; Antolak, Hubert; Pawlikowska, Ewelina; Kręgiel, Dorota; Sharifi-Rad, Javad; Oyeleye, Sunday I.; Ademiluyi, Adedayo O.; Czopek, Katarzyna; Staniak, Mariola; Custódio, Luísa; Coy-Barrera, Ericsson; Segura-Carretero, Antonio; de la Luz Cádiz-Gurrea, María; Capasso, Raffaele; Cho, William C.; Seca, Ana M. L.
    Euphorbia genus (Euphorbiaceae family), which is the third largest genus of angiosperm plants comprising ca. 2000 recognized species, is used all over the world in traditional medicine, especially in the traditional Chinese medicine. Members of this taxa are promptly recognizable by their specialized inflorescences and latex. In this review, an overview of Euphorbia-derived natural products such as essential oils, extracts, and pure compounds, active in a broad range of biological activities, and with potential usages in health maintenance, is described. The chemical composition of essential oils from Euphorbia species revealed the presence of more than 80 phytochemicals, mainly oxygenated sesquiterpenes and sesquiterpenes hydrocarbons, while Euphorbia extracts contain secondary metabolites such as sesquiterpenes, diterpenes, sterols, flavonoids, and other polyphenols. The extracts and secondary metabolites from Euphorbia plants may act as active principles of medicines for the treatment of many human ailments, mainly inflammation, cancer, and microbial infections. Besides, Euphorbia-derived products have great potential as a source of bioactive extracts and pure compounds, which can be used to promote longevity with more health.
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    The agricultural and therapeutic potential of Lavatera thuringiaca L. (Malvaceae)
    (Acta Agrobotanica, 2023) Staniak, Mariola; Kowalska, Iwona; Ruhul, Amin; Sharifi-Rad, Javad; Czopek, Katarzyna; Stępień-Warda, Anna
    One of the poorly recognized plant species well adapted to cultivation in temperate climate conditions is Lavatera thuringiaca L. It is a common species in Europe, but so far has not found much economic use. Few literature data report its high production potential, favorable chemical composition of biomass, resistance to adverse stress conditions, and medicinal properties. e biomass can be used for fodder and energy purposes and as forage for bees and other pollinators. L. thuringiaca can also be useful for the management of fallow soils or marginal land and for the reclamation of contaminated land. In turn, the presence of biologically active compounds offers opportunities for its use in medicine. Wider diversification of cultivated species is a key to ensuring food security and economic sustainability, especially in view of the observed climate change. In this context, an extensive review of literature dealing with taxonomic studies, morphological diversity and biological properties of L. thuringiaca, and the potential for multipurpose use of this species has been carried out.
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    The Therapeutic Potential of the Labdane Diterpenoid Forskolin
    (MDPI, 2019) Salehi, Bahare; Staniak, Mariola; Czopek, Katarzyna; Stępień, Anna; Dua, Kamal; Wadhwa, Ridhima; Chellappan, Dinesh Kumar; Sytar, Oksana; Brestic, Marian; Bhat, Namrata Ganesh; Kumar, Nanjangud Venkatesh Anil; del Mar Contreras, María; Sharopov, Farukh; Cho, William C.; Sharifi-Rad, Javad
    Forskolin is mainly found in the root of a plant called Coleus forskohlii (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological e ect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.